Abstract
Haemolysin A of Escherichia coli and listeriolysin of Listeria monocytogenes represent important bacterial virulence factors. While such cytolysins are usually the reason for morbidity and even mortality, vaccine researchers have turned haemolysin A and listeriolysin into tools for vaccine delivery. Both cytolysins have found widespread application in vaccine research and are highly suitable for the elicitation of cell-mediated immunity. In this paper, we will review vaccine delivery mediated by the haemolysin A secretion system and listeriolysin and will highlight their use in vaccination approaches against protozoan parasites.
MeSH terms
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Antigens / immunology
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Antiprotozoal Agents / immunology
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Bacterial Toxins / immunology
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Drug Delivery Systems
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Escherichia coli Proteins / immunology*
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Heat-Shock Proteins / immunology*
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Hemolysin Proteins / immunology*
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Humans
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Immunity, Cellular / immunology*
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Listeria monocytogenes / immunology
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Protozoan Infections / immunology
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Protozoan Infections / prevention & control*
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Vaccination / methods
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Vaccines, Attenuated / administration & dosage*
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Vaccines, Attenuated / immunology
Substances
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Antigens
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Antiprotozoal Agents
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Bacterial Toxins
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Escherichia coli Proteins
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Heat-Shock Proteins
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Hemolysin Proteins
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Hlya protein, E coli
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Vaccines, Attenuated
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hlyA protein, Listeria monocytogenes