N-ferrocenylmethyl, N'-methyl-2-substituted benzimidazolium iodide salts with in vitro activity against the Leishmania infantum parasite strain L1

Bioorg Med Chem Lett. 2003 Jun 16;13(12):2017-20. doi: 10.1016/s0960-894x(03)00327-5.

Abstract

Herein, we disclose results of our research into a class of benzimidazolium compounds active against the Leishmania infantum parasite strain L1. We have discovered that N-ferrocenylmethyl, N'-methyl-2-aryl (or styryl) benzimidazolium iodide salts show in vitro activity against this strain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzimidazoles / chemistry*
  • Benzimidazoles / pharmacology*
  • Ferrous Compounds / chemistry
  • Ferrous Compounds / pharmacology
  • Inhibitory Concentration 50
  • Iodides / chemistry
  • Iodides / pharmacology
  • Leishmania infantum / drug effects*
  • Leishmania infantum / genetics
  • Metallocenes
  • Structure-Activity Relationship
  • Trypanocidal Agents / chemistry*
  • Trypanocidal Agents / pharmacology*

Substances

  • Benzimidazoles
  • Ferrous Compounds
  • Iodides
  • Metallocenes
  • Trypanocidal Agents
  • ferrocene