Abstract
1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives have been synthesised and their in vitro activity against Plasmodium falciparum (malaria) Ghana, Trypanasoma b brucei (sleeping sickness) TB-1, and Trypanasoma cruzi (Chagas' disease) TC-1, and Leishmaniasis infantum (leishmaniasis) L1 parasite strains has been assessed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemical synthesis
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Alkanes / chemistry*
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Alkanes / pharmacology*
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Animals
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Antiprotozoal Agents / chemical synthesis
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Antiprotozoal Agents / pharmacology*
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / pharmacology
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Cell Line
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Humans
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Inhibitory Concentration 50
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Leishmania infantum / drug effects*
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Plasmodium falciparum / drug effects*
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Structure-Activity Relationship
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Trypanosoma brucei brucei / drug effects*
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Trypanosoma cruzi / drug effects*
Substances
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Alkanes
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Antiprotozoal Agents
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Bridged-Ring Compounds