1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives with in vitro activity against Plasmodium falciparum, Trypanasoma b brucei, Trypanasoma cruzi, and Leishmaniasis infantum

Bioorg Med Chem Lett. 2003 Jun 16;13(12):2013-5. doi: 10.1016/s0960-894x(03)00326-3.

Abstract

1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives have been synthesised and their in vitro activity against Plasmodium falciparum (malaria) Ghana, Trypanasoma b brucei (sleeping sickness) TB-1, and Trypanasoma cruzi (Chagas' disease) TC-1, and Leishmaniasis infantum (leishmaniasis) L1 parasite strains has been assessed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemical synthesis
  • Alkanes / chemistry*
  • Alkanes / pharmacology*
  • Animals
  • Antiprotozoal Agents / chemical synthesis
  • Antiprotozoal Agents / pharmacology*
  • Bridged-Ring Compounds / chemistry
  • Bridged-Ring Compounds / pharmacology
  • Cell Line
  • Humans
  • Inhibitory Concentration 50
  • Leishmania infantum / drug effects*
  • Plasmodium falciparum / drug effects*
  • Structure-Activity Relationship
  • Trypanosoma brucei brucei / drug effects*
  • Trypanosoma cruzi / drug effects*

Substances

  • Alkanes
  • Antiprotozoal Agents
  • Bridged-Ring Compounds