Abstract
Nicotinic acetylcholine receptors have been suggested to participate in morphogenetic processes during development of the nervous system. In this study, nicotine applied both in ovo and in vitro produced a reduction of the neuritic length of cholinoceptive neurons of the developing chick tectum, whereas alpha-bungarotoxin produced the opposite effect. Taken together with previous data, our results are indicative of a role of the alpha-bungarotoxin-sensitive nicotinic receptors in neural development.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bungarotoxins / pharmacology*
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Cells, Cultured
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Chick Embryo
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Dendrites / drug effects*
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Dendrites / physiology
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Ganglionic Stimulants / pharmacology*
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Mesencephalon / drug effects
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Mesencephalon / embryology
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Mesencephalon / metabolism
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Microtubule-Associated Proteins / metabolism
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Neurites / drug effects
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Neurites / physiology
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Nicotine / pharmacology*
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Receptors, Nicotinic / classification
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Receptors, Nicotinic / metabolism
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Superior Colliculi / cytology*
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Superior Colliculi / embryology
Substances
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Bungarotoxins
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Ganglionic Stimulants
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Microtubule-Associated Proteins
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Receptors, Nicotinic
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Nicotine