Preparation of poly(lactic acid) composites containing calcium carbonate (vaterite)

Biomaterials. 2003 Aug;24(19):3247-53. doi: 10.1016/s0142-9612(03)00190-x.

Abstract

A new type of ceramic-polymer biomaterial having excellent apatite-forming ability in simulated body fluid was prepared by hot-pressing a mixture of poly(-L-lactic acid) (PLA) and calcium carbonate (vaterite). After PLA dissolved in methylene chloride was mixed with calcium carbonate consisting of vaterite, the mixture was dried completely and subsequently hot-pressed uniaxially under a pressure of 40 MPa at 180 degrees C. When 30 wt% vaterite was introduced, the modulus of elasticity was effectively improved by 3.5-6 GPa, which was about twice higher than the modulus of PLA. The composite showed no brittle fracture behavior and a comparably high bending strength of approximately 50 MPa. The composite containing 30 wt% vaterite formed a 5-15-microm-thick bonelike apatite layer on its surface after soaking in SBF at 37 degrees C even for 1-3d.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apatites
  • Biocompatible Materials
  • Bone Substitutes
  • Calcium Carbonate / chemistry*
  • Lactic Acid / chemistry*
  • Magnetic Resonance Spectroscopy
  • Materials Testing
  • Methylene Chloride / chemistry
  • Microscopy, Electron, Scanning
  • Polyesters
  • Polymers / chemistry*

Substances

  • Apatites
  • Biocompatible Materials
  • Bone Substitutes
  • Polyesters
  • Polymers
  • Lactic Acid
  • poly(lactide)
  • Methylene Chloride
  • Calcium Carbonate