The fate of the prion protein in the prion/plasminogen complex

Biochem Biophys Res Commun. 2003 Jun 6;305(3):518-22. doi: 10.1016/s0006-291x(03)00804-0.

Abstract

The cellular prion protein (PrP(c)) forms complexes with plasminogen. Here, we show that the PrP(c) in this complex is cleaved to yield fragments of PrP(c). The cleavage is accelerated by plasmin but does not appear to be dependent on it.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electrophoresis, Polyacrylamide Gel
  • Fibrinolysin / metabolism
  • Humans
  • Macromolecular Substances
  • Peptide Fragments / metabolism
  • Plasminogen / metabolism*
  • PrPC Proteins / metabolism*
  • Sheep
  • Tissue Plasminogen Activator / metabolism

Substances

  • Macromolecular Substances
  • Peptide Fragments
  • PrPC Proteins
  • Plasminogen
  • Tissue Plasminogen Activator
  • Fibrinolysin