A multifactor complex of eIF1, eIF2, eIF3, eIF5, and tRNA(i)Met promotes initiation complex assembly and couples GTP hydrolysis to AUG recognition

Cold Spring Harb Symp Quant Biol. 2001:66:403-15. doi: 10.1101/sqb.2001.66.403.

Authors

K Asano¹, L Phan, L Valásek, L W Schoenfeld, A Shalev, J Clayton, K Nielsen, T F Donahue, A G Hinnebusch

Affiliation

¹ Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

PMID: 12762043
DOI: 10.1101/sqb.2001.66.403

No abstract available

Publication types

Review

MeSH terms

Animals
Base Sequence
Binding Sites
Biological Evolution
Conserved Sequence
Eukaryotic Initiation Factor-1 / genetics
Eukaryotic Initiation Factor-1 / metabolism*
Eukaryotic Initiation Factor-2 / genetics
Eukaryotic Initiation Factor-2 / metabolism*
Eukaryotic Initiation Factor-3 / genetics
Eukaryotic Initiation Factor-3 / metabolism*
Eukaryotic Initiation Factor-5 / genetics
Eukaryotic Initiation Factor-5 / metabolism*
Guanosine Triphosphate / metabolism*
Peptide Chain Initiation, Translational / genetics*
Protein Biosynthesis*
RNA, Transfer, Met / genetics
RNA, Transfer, Met / metabolism*
Saccharomyces cerevisiae / genetics

Substances

Eukaryotic Initiation Factor-1
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factor-3
Eukaryotic Initiation Factor-5
RNA, Transfer, Met
Guanosine Triphosphate