Abstract
A role for immunoregulatory T cells in the maintenance of self-tolerance and in transplantation tolerance has long been suggested, but the identification of such cells has not been achieved until recently. With the characterisation of spontaneously occurring CD4+CD25+ and NK1.1+ T subpopulations of T cells as regulatory cells in rodents and in humans, together with several in vitro generated regulatory T-cell populations, it seems possible that 'customised' regulatory cells possessing antidonor specificity may become therapeutic tools in clinical transplantation tolerance.
MeSH terms
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Animals
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Antibody Specificity
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Antigens, CD
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Antigens, Differentiation / physiology
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Autoimmunity*
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CD28 Antigens / biosynthesis
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CD3 Complex / biosynthesis
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CD4-Positive T-Lymphocytes / immunology
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CTLA-4 Antigen
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Humans
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Interleukin-10 / metabolism
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Killer Cells, Natural
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Rats
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Receptors, Interleukin-2 / biosynthesis
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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Transforming Growth Factor beta / metabolism
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Transplantation Tolerance*
Substances
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Antigens, CD
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Antigens, Differentiation
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CD28 Antigens
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CD3 Complex
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CTLA-4 Antigen
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CTLA4 protein, human
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Receptors, Interleukin-2
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Transforming Growth Factor beta
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Interleukin-10