Abstract
Analogs of 5-methoxymethyl-2'-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Antiviral Agents / toxicity
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Chromatography, High Pressure Liquid
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Crystallography, X-Ray
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Deamination / drug effects
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / chemical synthesis*
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Deoxycytidine / pharmacology
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Drug Stability
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Herpesvirus 1, Human / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Molecular Structure
Substances
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Antiviral Agents
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Deoxycytidine
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5-methoxymethyl-2-deoxycytidine