Building blocks for polyamide nucleic acids: facile synthesis using potassium fluoride doped natural phosphate as basic catalyst

Nucleosides Nucleotides Nucleic Acids. 2003 Feb;22(2):109-14. doi: 10.1081/NCN-120019491.

Abstract

Potassium fluoride doped natural phosphate, inexpensive and environmentally friendly catalyst, is shown to be an efficient basic catalyst for the N1/N9 alkylation of different nucleobases as synthons for PNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Catalysis
  • Fluorides / chemistry
  • Heterocyclic Compounds / chemistry
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Peptide Nucleic Acids / chemical synthesis*
  • Phosphates / chemistry
  • Potassium Compounds / chemistry

Substances

  • Heterocyclic Compounds
  • Peptide Nucleic Acids
  • Phosphates
  • Potassium Compounds
  • potassium fluoride
  • Fluorides