Abstract
The concentration of feline serum amyloid A (fSAA) was determined by a direct enzyme-linked immunosorbent assay (ELISA) by using fSAA specific monoclonal antibodies, to evaluate the fSAA as an inflammatory marker in cats. The mean concentration +/- standard deviation of fSAA was found to be 0.60 +/- 1.06 microg/m l and 33.65 +/- 67.59 microg/ml in serum samples from normal cats (n=45) and cats (n=312) with various diseases and disorders, respectively. A significant difference (p<0.001) was found between the two groups. It was also found that the concentration of fSAA begins to increase rapidly at approximately 3-6 hr after spay, and increases up to significantly high levels in some disorders, like injury, renal failure, infectious diseases, etc.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Biomarkers / blood
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Cat Diseases / blood
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Cat Diseases / diagnosis*
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Cats
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Communicable Diseases / blood
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Communicable Diseases / diagnosis
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Communicable Diseases / veterinary
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Diabetes Mellitus / blood
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Diabetes Mellitus / diagnosis
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Diabetes Mellitus / veterinary
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Enteritis / blood
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Enteritis / diagnosis
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Enteritis / veterinary
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Enzyme-Linked Immunosorbent Assay / veterinary
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Inflammation / blood
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Inflammation / diagnosis
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Inflammation / veterinary*
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Liver Diseases / blood
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Liver Diseases / diagnosis
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Liver Diseases / veterinary
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Mouth Diseases / blood
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Mouth Diseases / diagnosis
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Mouth Diseases / veterinary
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Neoplasms / blood
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Neoplasms / diagnosis
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Neoplasms / veterinary
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Renal Insufficiency / blood
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Renal Insufficiency / diagnosis
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Renal Insufficiency / veterinary
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Serum Amyloid A Protein / analysis*
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Serum Amyloid A Protein / immunology
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Urologic Diseases / blood
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Urologic Diseases / diagnosis
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Urologic Diseases / veterinary
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Wounds and Injuries / blood
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Wounds and Injuries / diagnosis
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Wounds and Injuries / veterinary
Substances
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Antibodies, Monoclonal
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Biomarkers
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Serum Amyloid A Protein