Abstract
The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review we will describe three nucleoside translocase I inhibitors, mureidomycin, tunicamycin and liposidomycin.
MeSH terms
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Aminoglycosides*
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Anti-Bacterial Agents* / pharmacology
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Bacteria* / drug effects
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Bacteria* / enzymology
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Bacteria* / metabolism
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Cell Wall* / drug effects
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Cell Wall* / metabolism
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Molecular Structure
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Nucleosides / pharmacology
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Peptidoglycan / biosynthesis*
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Peptidoglycan / drug effects
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Transferases (Other Substituted Phosphate Groups) / metabolism
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Tunicamycin / pharmacology
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Nucleosides
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Peptidoglycan
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liposidomycins
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Tunicamycin
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Transferases (Other Substituted Phosphate Groups)
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phospho-N-acetylmuramoyl pentapeptide transferase