Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis

Nat Prod Rep. 2003 Apr;20(2):252-73. doi: 10.1039/b202149h.

Abstract

The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review we will describe three nucleoside translocase I inhibitors, mureidomycin, tunicamycin and liposidomycin.

Publication types

  • Review

MeSH terms

  • Aminoglycosides*
  • Anti-Bacterial Agents* / pharmacology
  • Bacteria* / drug effects
  • Bacteria* / enzymology
  • Bacteria* / metabolism
  • Cell Wall* / drug effects
  • Cell Wall* / metabolism
  • Molecular Structure
  • Nucleosides / pharmacology
  • Peptidoglycan / biosynthesis*
  • Peptidoglycan / drug effects
  • Transferases (Other Substituted Phosphate Groups) / metabolism
  • Tunicamycin / pharmacology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Nucleosides
  • Peptidoglycan
  • liposidomycins
  • Tunicamycin
  • Transferases (Other Substituted Phosphate Groups)
  • phospho-N-acetylmuramoyl pentapeptide transferase