We present two fatal cases, a 41-year-old male (case 1) and his 8-year-old daughter (case 2), resulting from acute lidocaine poisoning. Lidocaine was quantified by gas chromatography (GC) analysis using nitrogen-phosphorus detection. The lidocaine concentrations of cases 1 and 2 were: liver, 27.7 microg/g and 24.9 microg/g; spleen, 70.1 microg/g and 29.9 microg/g; and gastric contents, 23.6 microg/g and 42.8 microg/g, respectively.