Abstract
Four mitochondrial proteins have been identified that immunoprecipitate with the mammalian inhibitor of apoptosis (IAP) protein XIAP. Each of them interacts via a processed amino terminus that resembles those of the insect pro-apoptotic IAP binding proteins Grim, HID, Reaper, and Sickle. Two, Diablo/Smac and HrtA2/Omi, have been extensively characterized. Both Diablo and HtrA2 can bind to IAPs and promote apoptosis when over-expressed in transfected cells, but unlike the insect IAP antagonists, to date there is scant evidence that they are important regulators of apoptosis in more physiological circumstances.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis Regulatory Proteins
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Apoptosis*
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Carrier Proteins / metabolism*
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High-Temperature Requirement A Serine Peptidase 2
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Inhibitor of Apoptosis Proteins
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Intracellular Signaling Peptides and Proteins
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Mammals / metabolism
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Mitochondrial Proteins / metabolism*
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Models, Biological
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Neoplasms / drug therapy
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Neoplasms / pathology
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Proteins / metabolism*
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Serine Endopeptidases / metabolism
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X-Linked Inhibitor of Apoptosis Protein
Substances
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Apoptosis Regulatory Proteins
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Carrier Proteins
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DIABLO protein, human
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Inhibitor of Apoptosis Proteins
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Intracellular Signaling Peptides and Proteins
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Mitochondrial Proteins
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Proteins
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X-Linked Inhibitor of Apoptosis Protein
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Serine Endopeptidases
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HTRA2 protein, human
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High-Temperature Requirement A Serine Peptidase 2