Antifungal activity of a thiophene polyine from Leuzea carthamoides

V Chobot; V Buchta; H Jahodárová; M Pour; L Opletal; L Jahodár; P Harant

doi:10.1016/s0367-326x(03)00027-3

Antifungal activity of a thiophene polyine from Leuzea carthamoides

Fitoterapia. 2003 Apr;74(3):288-90. doi: 10.1016/s0367-326x(03)00027-3.

Authors

V Chobot¹, V Buchta, H Jahodárová, M Pour, L Opletal, L Jahodár, P Harant

Affiliation

¹ Department of Pharmaceutical Botany and Ecology, Charles University, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové 500 05, Czech Republic.

PMID: 12727496
DOI: 10.1016/s0367-326x(03)00027-3

Abstract

The thiophene polyine (E)-2-[5-(hept-5-en-1,3-diynyl)-thien-2-yl]-ethan-1,2-diol was isolated from an ethanolic extract of underground parts of Leuzea carthamoides. The thiophene polyine demonstrated significant antifungal activity against all tested species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absidia / drug effects
Antifungal Agents / administration & dosage
Antifungal Agents / pharmacology*
Antifungal Agents / therapeutic use
Aspergillus / drug effects
Asteraceae*
Candida / drug effects
Humans
Microbial Sensitivity Tests
Phytotherapy*
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Thiophenes / administration & dosage
Thiophenes / pharmacology*
Thiophenes / therapeutic use
Trichophyton / drug effects

Substances

Antifungal Agents
Plant Extracts
Thiophenes