Abstract
Weekly infusion of high-dose 5-FU through the hepatic artery after resection of colorectal cancer was compared with resection alone in patients with multiple liver metastases. Twenty-seven patients (Group I) underwent hepatic artery infusion chemotherapy and 74 patients (Group II) underwent resection alone. The average survival time was 17.9 months in Group I and 8.5 months in Group II. One CR and 7 PR were achieved with arterial infusion therapy and the response rate was 29.6%. One- to three-year survivals were better in Group I than Group II.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antimetabolites, Antineoplastic / administration & dosage*
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Colonic Neoplasms / pathology*
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Combined Modality Therapy
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Drug Administration Schedule
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Female
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Fluorouracil / administration & dosage*
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Hepatectomy
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Hepatic Artery
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Humans
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Infusion Pumps, Implantable
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Infusions, Intra-Arterial
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / mortality
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Liver Neoplasms / secondary*
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Male
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Middle Aged
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Rectal Neoplasms / pathology*
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Retrospective Studies
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Survival Rate
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Treatment Outcome
Substances
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Antimetabolites, Antineoplastic
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Fluorouracil