Abstract
A novel immunosuppressive agent, FR252921 was isolated from the cultured broth of a species of Pseudomonas fluorescens. We have shown that FR252921 inhibit activating protein-1 (AP-1) transcription activity and act dominantly against antigen presenting cells comparing to T cell. Possibility of FR252921 as concomitant drug of FK506, T-cell specific inhibitor was evaluated. FR252921 showed synergy with FK506 in immunosuppressive activity both in splenic proliferation and in murine skin transplantation.
MeSH terms
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Animals
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Cell Division / drug effects
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Cell Division / immunology
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Drug Synergism
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Female
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Graft Survival / drug effects
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Graft Survival / immunology
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Immunosuppressive Agents / isolation & purification
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Immunosuppressive Agents / pharmacology*
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Lactams / isolation & purification
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Lactams / pharmacology*
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Lactones / isolation & purification
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Lactones / pharmacology*
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Lymphocyte Activation / drug effects
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mycophenolic Acid / analogs & derivatives
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Mycophenolic Acid / pharmacology
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Pseudomonas fluorescens / chemistry*
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Pseudomonas fluorescens / metabolism
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Skin Transplantation / immunology
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T-Lymphocytes / cytology
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
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Tacrolimus / pharmacology
Substances
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FR 252921
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Immunosuppressive Agents
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Lactams
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Lactones
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Mycophenolic Acid
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Tacrolimus