Abstract
Novel immunosuppressive agents, FR252921, FR252922 and FR256523 were isolated from the cultured broth of a bacterial strain No. 408813. The strain was identified Pseudomonas fluorescens from morphological and physiological characteristics. FR252921, FR252922 and FR256523, novel compounds containing macrolactone ring, showed immunosuppressive activity against murine splenocyte proliferation stimulated with lipopolysaccharide (LPS) or anti-CD3 mAb in vitro.
MeSH terms
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Animals
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Cell Division / drug effects
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Cell Division / immunology
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Cytotoxicity, Immunologic
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Female
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Fermentation
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / isolation & purification*
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Immunosuppressive Agents / pharmacology*
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Lactones / chemistry
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Lactones / immunology
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Lactones / isolation & purification*
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Lymphocyte Activation / immunology
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Mice
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Mice, Inbred BALB C
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Microscopy, Electron, Scanning
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Molecular Structure
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Molecular Weight
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Nuclear Magnetic Resonance, Biomolecular
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Optical Rotation
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Pseudomonas fluorescens / chemistry
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Pseudomonas fluorescens / classification
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Pseudomonas fluorescens / metabolism*
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Pseudomonas fluorescens / physiology
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Soil Microbiology
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Spectrometry, Mass, Fast Atom Bombardment
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology
Substances
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Immunosuppressive Agents
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Lactones