Abstract
Three new kapakahines E-G (1-3) have been isolated from the marine sponge Cribrochalina olemda. Limited quantities of these compounds required not only NMR analysis but also FAB-MS/MS analysis for the structure elucidation. Kapakahine E showed cytotoxicity against P388 murine leukemia cells. [structure: see text]
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Leukemia P388
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Nuclear Magnetic Resonance, Biomolecular
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Porifera / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Stereoisomerism
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Peptides, Cyclic
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kapakahine E
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kapakahine F
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kapakahine G