Axons guided by insulin receptor in Drosophila visual system

Science. 2003 Apr 18;300(5618):502-5. doi: 10.1126/science.1081203.

Abstract

Insulin receptors are abundant in the central nervous system, but their roles remain elusive. Here we show that the insulin receptor functions in axon guidance. The Drosophila insulin receptor (DInR) is required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system. DInR functions as a guidance receptor for the adapter protein Dock/Nck. This function is independent of Chico, the Drosophila insulin receptor substrate (IRS) homolog.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Axons / physiology*
  • Binding Sites
  • Blotting, Western
  • Brain / cytology
  • Brain / growth & development
  • Carrier Proteins / genetics
  • Carrier Proteins / immunology
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology*
  • Cell Differentiation
  • Cell Size
  • Drosophila / genetics
  • Drosophila / growth & development*
  • Drosophila / physiology
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Eye / cytology
  • Eye / growth & development
  • Female
  • Growth Cones / physiology
  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Mutation
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Photoreceptor Cells, Invertebrate / cytology
  • Photoreceptor Cells, Invertebrate / physiology*
  • Precipitin Tests
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / immunology
  • Protein-Tyrosine Kinases / metabolism
  • Protein-Tyrosine Kinases / physiology*
  • Receptor Protein-Tyrosine Kinases*
  • Receptor, Insulin / genetics
  • Receptor, Insulin / immunology
  • Receptor, Insulin / metabolism
  • Receptor, Insulin / physiology*
  • Retina / cytology
  • Retina / growth & development
  • Signal Transduction
  • Two-Hybrid System Techniques
  • Visual Pathways
  • src Homology Domains

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Drosophila Proteins
  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nerve Tissue Proteins
  • chico protein, Drosophila
  • dock protein, Drosophila
  • InR protein, Drosophila
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases
  • Receptor, Insulin