The detection of non-adherence by self-administered questionnaires can be optimized by protease inhibitor plasma concentration determination

AIDS. 2003 May 2;17(7):1096-9. doi: 10.1097/00002030-200305020-00025.

Abstract

Self-reported adherence and plasma protease inhibitor concentration (PPIC) were assessed in 642 HIV-infected patients at month 4 of a single protease inhibitor-containing regimen. PPIC was below the limit of quantification (LOQ) in 32% of non-adherent patients and in 8% of adherent patients. The relationship between non-adherence and a detectable HIV viral load was enhanced when adherent patients with PPIC below LOQ were considered to be non-adherent. PPIC combined with self-report may more reliably detect non-adherence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiretroviral Therapy, Highly Active
  • Cohort Studies
  • HIV Infections / drug therapy*
  • HIV Protease Inhibitors / therapeutic use*
  • Humans
  • Patient Compliance*
  • Self Disclosure
  • Sensitivity and Specificity
  • Surveys and Questionnaires
  • Viral Load

Substances

  • HIV Protease Inhibitors