Platelet purinergic receptors

Curr Opin Pharmacol. 2003 Apr;3(2):175-80. doi: 10.1016/s1471-4892(03)00007-9.

Abstract

Activation of P2Y(1) and P2Y(12) receptors, through secreted ADP that is stimulated by agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet activation. P2X(1) receptors also participate in platelet shape change and potentiation of calcium mobilization. The cloning of the P2Y(12) receptor and its subsequent knockout in mice promises further understanding of its downstream signaling events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism*
  • Blood Platelets / physiology
  • Humans
  • Platelet Activation / drug effects
  • Platelet Activation / physiology*
  • Platelet Aggregation / drug effects
  • Platelet Aggregation / physiology*
  • Receptors, Purinergic / chemistry
  • Receptors, Purinergic / physiology*

Substances

  • Receptors, Purinergic