5-FU-induced peripheral neuropathy: a rare complication of a well-known drug

Hanneke W M van Laarhoven; Carla C P Verstappen; Louk V A M Beex; Arnoud C Kappelle; Cornelis J A Punt

5-FU-induced peripheral neuropathy: a rare complication of a well-known drug

Anticancer Res. 2003 Jan-Feb;23(1B):647-8.

Authors

Hanneke W M van Laarhoven¹, Carla C P Verstappen, Louk V A M Beex, Arnoud C Kappelle, Cornelis J A Punt

Affiliation

¹ Department of Medical Oncology, University Medical Centre St. Radboud, P.O. Box 9101, 6500HB Nijmegen, The Netherlands. H.vanLaarhoven@onco.umcn.nl

PMID: 12680161

Abstract

Peripheral neuropathy is a rare complication of the commonly used cytotoxic drug 5-fluorouracil (5-FU). We report a case of 5-FU-induced peripheral neuropathy in a patient with metastatic colorectal carcinoma. Discontinuation of 5-FU therapy is recommended in case of 5-FU-related neurotoxicity.

Publication types

Case Reports

MeSH terms

Antimetabolites, Antineoplastic / adverse effects*
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Colorectal Neoplasms / drug therapy
Colorectal Neoplasms / pathology
Fluorouracil / administration & dosage
Fluorouracil / adverse effects*
Humans
Leucovorin / administration & dosage
Lung Neoplasms / drug therapy
Lung Neoplasms / secondary
Male
Middle Aged
Peripheral Nervous System Diseases / chemically induced*

Substances

Antimetabolites, Antineoplastic
Leucovorin
Fluorouracil