Objective: To study the role of ICE in Laryngeal Carcinoma.
Method: Using polyclonal antibody for ICE gene protein, 73 cases of laryngeal carcinoma, 30 cases dysplasia and 5 cases normal were stained by SP immunohistochemistry.
Result: ICE protein is situated mainly in the upper of epithelium and a little in the basal layer. Compared with the normal epithelium, the expression of ICE in the dysplasia is decreased significantly (P < 0.01). There is a relationship between expression of ICE in laryngeal carcinoma and the degree of differentiation. The better differentiation, the much expression of ICE (P < 0.05).
Conclusion: There is an intimate relationship between innormal expression protein of ICE and dysplasia, and that of between laryngeal carcinoma and prognosis. The expression of ICE may be a monitoring marker for prognosis of laryngeal carcinoma.