Modiolides A and B, two new 10-membered macrolides from a marine-derived fungus

Masashi Tsuda; Takao Mugishima; Kazusei Komatsu; Teruo Sone; Michiko Tanaka; Yuzuru Mikami; Jun'ichi Kobayashi

doi:10.1021/np0203943

Modiolides A and B, two new 10-membered macrolides from a marine-derived fungus

J Nat Prod. 2003 Mar;66(3):412-5. doi: 10.1021/np0203943.

Authors

Masashi Tsuda¹, Takao Mugishima, Kazusei Komatsu, Teruo Sone, Michiko Tanaka, Yuzuru Mikami, Jun'ichi Kobayashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 12662103
DOI: 10.1021/np0203943

Abstract

Two new 10-membered macrolides, modiolides A (1) and B (2), and a new linear pentaketide, modiolin (3), were isolated from the cultured broth of a fungus Paraphaeosphaeria sp. (N-119), which was separated from a marine horse mussel, and the structures were elucidated by spectroscopic data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bivalvia
Fungi / chemistry*
Japan
Macrolides / chemistry
Macrolides / isolation & purification*
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Macrolides
modiolide A
modiolide B