New acetylenic acids from the marine sponge Stelletta species

J Nat Prod. 2003 Mar;66(3):408-11. doi: 10.1021/np020440z.

Abstract

Four new acetylenic acids were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of CD spectroscopy and a chiral anisotropic reagent, phenylglycine methyl ester (PGME). The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines and exhibited marginal to moderate cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Circular Dichroism
  • Drug Screening Assays, Antitumor
  • Fatty Acids, Unsaturated / chemistry
  • Fatty Acids, Unsaturated / isolation & purification*
  • Fatty Acids, Unsaturated / pharmacology
  • Humans
  • Korea
  • Mass Spectrometry
  • Molecular Structure
  • Porifera / chemistry*
  • Stereoisomerism
  • Tumor Cells, Cultured / drug effects

Substances

  • Alkynes
  • Antineoplastic Agents
  • Fatty Acids, Unsaturated
  • 2-hexadecynoic acid