Abstract
Four new acetylenic acids were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of CD spectroscopy and a chiral anisotropic reagent, phenylglycine methyl ester (PGME). The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines and exhibited marginal to moderate cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Circular Dichroism
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Drug Screening Assays, Antitumor
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification*
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Fatty Acids, Unsaturated / pharmacology
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Humans
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Korea
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Mass Spectrometry
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Molecular Structure
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Porifera / chemistry*
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Stereoisomerism
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Tumor Cells, Cultured / drug effects
Substances
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Alkynes
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Antineoplastic Agents
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Fatty Acids, Unsaturated
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2-hexadecynoic acid