[Cerebral amyloid angiopathy revealed by transient ischemic events: contribution of MRI to diagnosis and pathophysiology study]

Rev Neurol (Paris). 2003 Feb;159(2):203-5.
[Article in French]

Abstract

We report the case of a 72-year-old left-handed woman presenting with episodes of paresthesias of the left arm and dysarthria consistent with transient ischemic attacks. The diffusion MRI showed hypersignals of the right corona radiata suggesting recent ischemic process whereas gradient-echo MRI revealed multiple small hypointense regions consistent with petechial hemorrhages restricted to the corticosubcortical regions. Gadolinium-enhanced, T1-weighted MRI showed focal meningeal enhancement. The diagnosis of cerebral amyloid angiopathy was supported by leptomeningeal biopsy. The association of ischemic suffering, petechial haemorrhage and meningeal enhancement as demonstrated by multisequence MRI highly suggest a cerebral amyloid angiopathy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Cerebral Amyloid Angiopathy / diagnosis*
  • Cerebral Amyloid Angiopathy / etiology
  • Cerebral Amyloid Angiopathy / physiopathology
  • Cerebral Cortex / pathology
  • Cerebral Hemorrhage / pathology
  • Dysarthria / etiology
  • Echo-Planar Imaging
  • Electrocardiography
  • Female
  • Gadolinium
  • Humans
  • Ischemic Attack, Transient / complications*
  • Ischemic Attack, Transient / physiopathology
  • Magnetic Resonance Imaging
  • Meninges / pathology
  • Paresthesia / etiology

Substances

  • Gadolinium