Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol

Angew Chem Int Ed Engl. 2003 Mar 17;42(11):1280-4. doi: 10.1002/anie.200390329.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology
  • Cell Division / drug effects
  • Cyclopropanes / chemical synthesis*
  • Cyclopropanes / chemistry
  • Cyclopropanes / pharmacology
  • Drug Design
  • HSP90 Heat-Shock Proteins / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Lactones / chemical synthesis*
  • Lactones / chemistry
  • Lactones / pharmacology
  • Macrolides
  • Molecular Structure
  • Protein Binding
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Cyclopropanes
  • HSP90 Heat-Shock Proteins
  • Lactones
  • Macrolides
  • cycloproparadicicol
  • monorden