Abstract
Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the anti-nociceptive and anti-inflammatory effect of C. bancoesnsis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemistry
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Analgesics / isolation & purification*
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Analgesics / therapeutic use
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Araliaceae / chemistry*
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Disease Models, Animal
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Edema / drug therapy
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Korea
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Male
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Medicine, East Asian Traditional
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Mice
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Mice, Inbred ICR
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Molecular Structure
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Pain / drug therapy
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Plant Bark / chemistry
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Plant Extracts
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Plant Leaves / chemistry
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Rats
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Rats, Sprague-Dawley
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / therapeutic use
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Ursolic Acid
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Plant Extracts
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Triterpenes
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23-hydroxyursolic acid