In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis

Arch Pharm Res. 2003 Feb;26(2):143-6. doi: 10.1007/BF02976660.

Abstract

Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the anti-nociceptive and anti-inflammatory effect of C. bancoesnsis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / chemistry
  • Analgesics / isolation & purification*
  • Analgesics / therapeutic use
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Araliaceae / chemistry*
  • Disease Models, Animal
  • Edema / drug therapy
  • Korea
  • Male
  • Medicine, East Asian Traditional
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Pain / drug therapy
  • Plant Bark / chemistry
  • Plant Extracts
  • Plant Leaves / chemistry
  • Rats
  • Rats, Sprague-Dawley
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / therapeutic use
  • Ursolic Acid

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Extracts
  • Triterpenes
  • 23-hydroxyursolic acid