Abstract
As part of a program to determine the genetic diversity of human immunodeficiency virus in rural Kenya, we carried out a molecular analysis of the C2-V3 region of HIV-infected blood samples obtained from 30 antenatal clinic attendees of seven health centers in western Kenya. Direct sequencing was carried out on the envelope C2-V3 region of proviral DNA. On phylogenetic analysis with reference strains, 20 were subtype Al, 2 were subtype D, 1 was subtype C, 1 was subtype G, 1 was CRF-10, 2A/D, 2A/C, and 2 were unclassified. The presence of CRF-10 and the great variety of subtypes and recombinants in such a limited sample size suggest that western Kenya may be a potential hotspot for HIV recombination in the country.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Amino Acid Sequence
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DNA, Viral / blood
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Gene Products, env / genetics*
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Genetic Variation*
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HIV Envelope Protein gp120 / genetics
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HIV Infections / epidemiology*
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HIV Infections / virology
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HIV-1 / classification*
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HIV-1 / genetics
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Humans
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Kenya / epidemiology
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Molecular Sequence Data
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Peptide Fragments / genetics
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Phylogeny
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Proviruses
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Recombination, Genetic*
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Rural Population*
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Sequence Analysis, DNA
Substances
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DNA, Viral
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Gene Products, env
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HIV Envelope Protein gp120
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HIV envelope protein gp120 (305-321)
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Peptide Fragments
Associated data
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GENBANK/AY166877
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GENBANK/AY166878
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GENBANK/AY166879
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GENBANK/AY166880
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GENBANK/AY166881
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GENBANK/AY166882
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GENBANK/AY166883
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GENBANK/AY166884
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GENBANK/AY166885
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GENBANK/AY166886
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GENBANK/AY166887
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GENBANK/AY166888
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GENBANK/AY166889
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GENBANK/AY166890
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GENBANK/AY166891
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GENBANK/AY166892
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GENBANK/AY166893
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GENBANK/AY166894
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GENBANK/AY166895
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GENBANK/AY166896
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GENBANK/AY166897
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GENBANK/AY166898
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GENBANK/AY166899
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GENBANK/AY166900
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GENBANK/AY166901
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GENBANK/AY166902
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GENBANK/AY166903
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GENBANK/AY166904
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GENBANK/AY166905
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GENBANK/AY166906