Abstract
Genotyping of sixteen exfoliative toxin-producing (ET-positive) strains of Staphylococcus aureus isolated in maternity units of two distant hospitals was accomplished by PFGE, ribotyping, PCR ribotyping, and prophage carriage. Three strains secreted combined ETA + ETB, and the remaining produced ETA and enterotoxin C, or TSST-1. The comparison of various genomic profiles resulted in the identification of nine genotypes. The presence of one prevailing genotype was demonstrated in each hospital. Evidence was given that the outbreak-related ET-positive strains causing the skin disease pemphigus neonatorum disseminated in both the hospitals did not originate from a single source or a common ancestor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Bacterial Typing Techniques*
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Blister / epidemiology
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Blister / microbiology
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Cross Infection / epidemiology
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Cross Infection / microbiology
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Disease Outbreaks*
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Electrophoresis, Gel, Pulsed-Field
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Exfoliatins / biosynthesis*
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Female
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Genotype
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Hospitals, Maternity*
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Humans
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Infant, Newborn
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Polymerase Chain Reaction
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Pregnancy
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Prophages
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Ribotyping
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Staphylococcal Scalded Skin Syndrome / epidemiology
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Staphylococcal Scalded Skin Syndrome / microbiology
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Staphylococcal Skin Infections / epidemiology*
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Staphylococcal Skin Infections / microbiology
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Staphylococcus aureus / classification*
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Staphylococcus aureus / genetics*
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Staphylococcus aureus / metabolism
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Staphylococcus aureus / virology