Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report

P Kontoleon; I Ilias; D A Koutras; D Kontogiannis; P D Papapetrou

Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report

Clin Exp Obstet Gynecol. 2002;29(4):304-5.

Authors

P Kontoleon¹, I Ilias, D A Koutras, D Kontogiannis, P D Papapetrou

Affiliation

¹ Second Endocrine Department, Alexandra General Hospital, Athens, Greece.

PMID: 12635752

Abstract

We report the case of a 27-year-old woman with hyperthyroidism during pregnancy. Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ). The remaining pregnancy, delivery and follow-up period were uneventful for the mother and her offspring. Antithyroid treatment during pregnancy should allow the use not only of PTU but also of CBZ and methimazole.

Publication types

Case Reports

MeSH terms

Adult
Antithyroid Agents / administration & dosage
Antithyroid Agents / adverse effects
Antithyroid Agents / therapeutic use*
Carbimazole / administration & dosage
Carbimazole / therapeutic use*
Chemical and Drug Induced Liver Injury / diagnosis*
Chemical and Drug Induced Liver Injury / etiology
Diagnosis, Differential
Female
Humans
Hyperthyroidism / drug therapy*
Pregnancy
Pregnancy Complications / drug therapy*
Prenatal Care
Propylthiouracil / adverse effects*

Substances

Antithyroid Agents
Propylthiouracil
Carbimazole