Abstract
Following vaccination with defined tumor antigens that are recognized by T cells, a small proportion of cancer patients display tumor regressions. Several reports describe anti-vaccine T-cell responses, evaluated with a variety of methods, for example, by assessing T-cell function or expression of specific TCR. However, a correlation between these T-cell responses and the tumor regressions has not yet been established. It appears that some patients display tumor regression with an unexpectedly low frequency of anti-vaccine T cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antigens, Neoplasm / immunology
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Cancer Vaccines / genetics
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Cancer Vaccines / therapeutic use*
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Dendritic Cells / immunology
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Gene Expression Regulation, Neoplastic
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Humans
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Melanoma / drug therapy
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Melanoma / genetics
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Melanoma / immunology
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Monitoring, Immunologic / methods
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Neoplasm Proteins / immunology
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Receptors, Antigen, T-Cell / genetics
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
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Vaccination
Substances
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Antigens, Neoplasm
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Cancer Vaccines
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MAGEA3 protein, human
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Neoplasm Proteins
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Receptors, Antigen, T-Cell