Chronic myeloid leukaemia at the Kenyatta National Hospital, Nairobi

East Afr Med J. 2002 Nov;79(11):593-7. doi: 10.4314/eamj.v79i11.8805.

Abstract

Objective: To determine the clinical and haematological factors associated with treatment and outcome of chronic myeloid leukaemia (CML) at Kenyatta National Hospital.

Design: Retrospective survey of patients treated for chronic myeloid leukaemia.

Setting: Kenyatta National hospital, Nairobi, Kenya, between April 1990 and August 2000.

Subjects: Patients with chronic myeloid leukaemia.

Results: One hundred and four patients, 55 males and 49 females, age range 10-72 years with a median age of 35 years. Treatment with busulphan getting less popular in favour of hydroxyurea. Median follow-up 20 months with none of the clinical and haematological parameters impacting significantly on duration of follow-up.

Conclusion: CML occurs at a younger age-group in Kenya, and none of the clinical or haematological parameters appears to impact on follow-up duration.

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Busulfan / administration & dosage
  • Child
  • Female
  • Humans
  • Hydroxyurea / administration & dosage
  • Kenya
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / epidemiology*
  • Leukocyte Count
  • Male
  • Middle Aged
  • Retrospective Studies
  • Severity of Illness Index
  • Splenomegaly / classification
  • Splenomegaly / etiology
  • Survival Analysis
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Alkylating
  • Busulfan
  • Hydroxyurea