Abstract
In the present paper, we wish to report the synthesis and antinociceptive activity of a series of new azaalkane bis(2-aminoimidazolinium) compounds from which, N,N'-di(4,5-dihydro-1H-imidazol-2-yl)-3-aza-1,6-hexanediamine 2a has shown the best analgesic properties in vivo in two different assays (i.e., acetic acid-induced writhing test and hot-plate test in mice), as well as oral bioavailability.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid
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Analgesics, Non-Narcotic / chemical synthesis*
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Analgesics, Non-Narcotic / pharmacokinetics
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Analgesics, Non-Narcotic / pharmacology*
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Animals
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Aza Compounds / chemical synthesis*
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Aza Compounds / pharmacology*
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Biological Availability
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Dose-Response Relationship, Drug
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Guanidine / analogs & derivatives*
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Guanidine / chemical synthesis*
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Guanidine / pharmacology*
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Guinea Pigs
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Hot Temperature
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology*
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In Vitro Techniques
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Molecular Conformation
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Muscle Contraction / drug effects
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Muscle, Skeletal / drug effects
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Pain Measurement / drug effects
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Reaction Time / drug effects
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Spectrophotometry, Infrared
Substances
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Analgesics, Non-Narcotic
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Aza Compounds
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Imidazoles
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Indicators and Reagents
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Guanidine
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Acetic Acid