Significant variations of responsiveness of rat gut smooth muscles to glutamate

Dragan R Milovanovic; Milovan Matovic; Biljana Milicic; Slobodan M Jankovic

Significant variations of responsiveness of rat gut smooth muscles to glutamate

Pol J Pharmacol. 2002 Sep-Oct;54(5):507-11.

Authors

Dragan R Milovanovic¹, Milovan Matovic, Biljana Milicic, Slobodan M Jankovic

Affiliation

¹ Department of Pharmacology, Medical Faculty, University of Kragujevac, Svetozara Markovica 69, P.O. Box 124, 34000 Kragujevac, Serbia, FR Yugoslavia. piki@ptt.yu

PMID: 12593538

Abstract

Our four-year study, conducted on isolated rat stomach and rectum strips from adult rats of the same brood in five series, demonstrated for the first time notable variations of the responsiveness of the gut smooth muscles to glutamate, the findings that point to strong variability of glutamate contractile action which could lead to inconsistencies and should be taken into account in the future research.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Female
Glutamic Acid / pharmacology*
In Vitro Techniques
Male
Muscle Contraction / drug effects
Muscle, Smooth / drug effects*
Muscle, Smooth / physiology
Rats
Rectum / drug effects
Rectum / physiology
Stomach / drug effects
Stomach / physiology
Vasoconstrictor Agents / pharmacology*

Substances

Vasoconstrictor Agents
Glutamic Acid