Meliternatin: a feeding deterrent and larvicidal polyoxygenated flavone from Melicope subunifoliolata

Shuit Hung Ho; Jing Wang; K Y Sim; Gwendoline C L Ee; Zamrie Imiyabir; K F Yap; Khozirah Shaari; Swee Hock Goh

doi:10.1016/s0031-9422(02)00632-5

Meliternatin: a feeding deterrent and larvicidal polyoxygenated flavone from Melicope subunifoliolata

Phytochemistry. 2003 Apr;62(7):1121-4. doi: 10.1016/s0031-9422(02)00632-5.

Authors

Shuit Hung Ho¹, Jing Wang, K Y Sim, Gwendoline C L Ee, Zamrie Imiyabir, K F Yap, Khozirah Shaari, Swee Hock Goh

Affiliation

¹ Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. dbshosh@nus.edu.sg

PMID: 12591266
DOI: 10.1016/s0031-9422(02)00632-5

Abstract

We screened more than 60 Malaysian plants against two species of insects and found that Melicope subunifoliolata (Stapf) T.G. Hartley (Rutaceae) showed strong feeding deterrent activity against Sitophilus zeamais Motsch. (Curculionidae) and very good larvicidal activity against Aedes aegypti L. (Diptera). One anti-insect compound, meliternatin (3,5-dimethoxy-3',4',6,7-bismethylendioxyflavone) (6) and six other minor polyoxygenated flavones were isolated from M. subunifoliolata.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aedes / growth & development
Animals
Coleoptera / growth & development
Eating / drug effects
Flavonoids / chemistry*
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Insecticides / chemistry*
Insecticides / isolation & purification
Insecticides / pharmacology*
Larva / growth & development
Lethal Dose 50
Nuclear Magnetic Resonance, Biomolecular
Rutaceae / chemistry*

Substances

Flavonoids
Insecticides
meliternatin