RNA-modifying enzymes

Curr Opin Struct Biol. 2003 Feb;13(1):49-55. doi: 10.1016/s0959-440x(02)00002-7.

Abstract

A bewildering number of post-transcriptional modifications are introduced into cellular RNAs by enzymes that are often conserved among archaea, bacteria and eukaryotes. The modifications range from those with well-understood functions, such as tRNA aminoacylation, to widespread but more mysterious ones, such as pseudouridylation. Recent structure determinations have included two types of RNA nucleobase modifying enzyme: pseudouridine synthases and tRNA guanine transglycosylases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Binding Sites
  • Catalysis
  • Hydro-Lyases / chemistry*
  • Hydro-Lyases / metabolism
  • Macromolecular Substances
  • Models, Molecular*
  • Nucleic Acid Conformation
  • Pentosyltransferases / chemistry*
  • Pentosyltransferases / metabolism
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • Pseudouridine / chemistry
  • RNA / chemistry*
  • RNA / metabolism
  • RNA, Transfer / chemistry
  • RNA, Transfer / metabolism
  • Structure-Activity Relationship
  • Substrate Specificity

Substances

  • Macromolecular Substances
  • Pseudouridine
  • RNA
  • RNA, Transfer
  • Pentosyltransferases
  • queuine tRNA-ribosyltransferase
  • Hydro-Lyases
  • pseudouridylate synthetase