Abstract
A bewildering number of post-transcriptional modifications are introduced into cellular RNAs by enzymes that are often conserved among archaea, bacteria and eukaryotes. The modifications range from those with well-understood functions, such as tRNA aminoacylation, to widespread but more mysterious ones, such as pseudouridylation. Recent structure determinations have included two types of RNA nucleobase modifying enzyme: pseudouridine synthases and tRNA guanine transglycosylases.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Binding Sites
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Catalysis
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Hydro-Lyases / chemistry*
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Hydro-Lyases / metabolism
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Macromolecular Substances
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Models, Molecular*
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Nucleic Acid Conformation
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Pentosyltransferases / chemistry*
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Pentosyltransferases / metabolism
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Protein Binding
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Protein Conformation
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Protein Structure, Tertiary
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Pseudouridine / chemistry
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RNA / chemistry*
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RNA / metabolism
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RNA, Transfer / chemistry
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RNA, Transfer / metabolism
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Structure-Activity Relationship
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Substrate Specificity
Substances
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Macromolecular Substances
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Pseudouridine
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RNA
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RNA, Transfer
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Pentosyltransferases
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queuine tRNA-ribosyltransferase
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Hydro-Lyases
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pseudouridylate synthetase