Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar

Curr Opin Struct Biol. 2003 Feb;13(1):40-8. doi: 10.1016/s0959-440x(03)00012-5.

Abstract

It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFbeta-DNA, NFAT-Fos-Jun-DNA, GABPalpha-GABPbeta-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPbeta-DNA complex), and their regulatory mechanisms.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • CCAAT-Enhancer-Binding Proteins / chemistry
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Core Binding Factor Alpha 2 Subunit
  • DNA / chemistry*
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Eukaryotic Cells / chemistry*
  • Eukaryotic Cells / metabolism
  • Eukaryotic Cells / physiology
  • Gene Expression Regulation
  • Genes, Regulator
  • Macromolecular Substances
  • Models, Molecular*
  • Nucleic Acid Conformation
  • Promoter Regions, Genetic
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-myb / chemistry
  • Proto-Oncogene Proteins c-myb / metabolism
  • Proto-Oncogene Proteins*
  • Transcription Factor AP-2
  • Transcription Factor CHOP
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism
  • Transcription, Genetic*

Substances

  • CCAAT-Enhancer-Binding Proteins
  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins
  • Macromolecular Substances
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myb
  • Transcription Factor AP-2
  • Transcription Factors
  • Transcription Factor CHOP
  • DNA