Abstract
It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFbeta-DNA, NFAT-Fos-Jun-DNA, GABPalpha-GABPbeta-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPbeta-DNA complex), and their regulatory mechanisms.
MeSH terms
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Binding Sites
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CCAAT-Enhancer-Binding Proteins / chemistry
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CCAAT-Enhancer-Binding Proteins / metabolism
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Core Binding Factor Alpha 2 Subunit
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DNA / chemistry*
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DNA / metabolism
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism
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Eukaryotic Cells / chemistry*
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Eukaryotic Cells / metabolism
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Eukaryotic Cells / physiology
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Gene Expression Regulation
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Genes, Regulator
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Macromolecular Substances
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Models, Molecular*
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Nucleic Acid Conformation
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Promoter Regions, Genetic
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Protein Binding
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Protein Conformation
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Protein Structure, Tertiary
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Proto-Oncogene Proteins c-myb / chemistry
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Proto-Oncogene Proteins c-myb / metabolism
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Proto-Oncogene Proteins*
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Transcription Factor AP-2
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Transcription Factor CHOP
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Transcription Factors / chemistry*
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Transcription Factors / metabolism
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Transcription, Genetic*
Substances
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CCAAT-Enhancer-Binding Proteins
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins
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Macromolecular Substances
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-myb
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Transcription Factor AP-2
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Transcription Factors
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Transcription Factor CHOP
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DNA