Bacterial RNA polymerases: the wholo story

Curr Opin Struct Biol. 2003 Feb;13(1):31-9. doi: 10.1016/s0959-440x(02)00005-2.

Abstract

Recent structural and biophysical results have provided unprecedented insights into the structure and function of the bacterial RNA polymerase holoenzyme as it goes through the steps of transcription initiation. Comparisons with structural analyses of evolutionarily unrelated RNA polymerases reveal unexpected general features of the initiation process.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacteria / chemistry
  • Bacteria / enzymology
  • Bacteria / metabolism
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Binding Sites
  • Crystallography / methods
  • DNA / chemistry*
  • DNA / metabolism
  • DNA-Directed RNA Polymerases / chemistry*
  • DNA-Directed RNA Polymerases / metabolism
  • Holoenzymes / chemistry
  • Holoenzymes / metabolism
  • Macromolecular Substances
  • Models, Molecular*
  • Promoter Regions, Genetic
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • RNA / biosynthesis
  • RNA / chemistry*
  • Sigma Factor / chemistry*
  • Sigma Factor / metabolism
  • Thermus / chemistry*
  • Thermus / enzymology
  • Thermus / metabolism

Substances

  • Bacterial Proteins
  • Holoenzymes
  • Macromolecular Substances
  • Sigma Factor
  • RNA
  • DNA
  • DNA-Directed RNA Polymerases