Comparing with Ara-Amp, the effects of the ethano-soluble extracts from the dried rhizoma of Garcinia oblougififolia Champ (GOC) on HBeAg and HBsAg expression in 2.2.15 cells, which came from transfected HepG2 cells with coloned HBV DNA, were studied. The results showed that the extracts of GOC had a marked inhibition effects on HBeAg adn HBsAg which expressed by 2.2.15 cells, the effective concentration was range from 195 to 780 micrograms/ml.