The Creutzfeldt-Jakob disease (CJD) belongs to the so-called prion diseases or transmissible spongiform encephalopathies. The iatrogenic transmission of the pathogen by direct contact with infectious tissue, tissue extracts and surgical instruments has been demonstrated. CJD is not an infectious disease in the usual sense. Transmission is not possible by normal social contact nor by nursing measures just as CJD can not be transferred by normal skin contact or contact with blood, serum or other patient' secretions. Therefore, CJD patients do not have to be isolated, because strict conformity to the generally recognized rules of hygiene is completely sufficient. The high resistance of prions to environmental influences requires the combination of different disinfection and sterilization measures before inactivation of the pathogen occurs and it is possible to exclude transmission by medical products.