A synthetic overview of new molecules with 5-HT1A binding affinities

Mini Rev Med Chem. 2003 Mar;3(2):77-93. doi: 10.2174/1389557033405278.

Abstract

The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT(1A)binding affinities. Specifically we focused our attention in the synthesis of compounds structurally related to arylpiperazine, 2-aminotetralin, and benzopyran derivatives.

Publication types

  • Review

MeSH terms

  • Animals
  • Antidepressive Agents / chemistry
  • Antidepressive Agents / metabolism*
  • Antidepressive Agents / pharmacology
  • Benzopyrans / chemistry
  • Benzopyrans / metabolism*
  • Benzopyrans / pharmacology
  • Binding Sites
  • Humans
  • Ligands
  • Piperazines / chemistry
  • Piperazines / metabolism*
  • Piperazines / pharmacology
  • Receptors, Serotonin / metabolism*
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists / chemistry
  • Serotonin Antagonists / metabolism
  • Serotonin Antagonists / pharmacology
  • Serotonin Receptor Agonists / chemistry
  • Serotonin Receptor Agonists / metabolism
  • Serotonin Receptor Agonists / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tetrahydronaphthalenes / chemistry
  • Tetrahydronaphthalenes / metabolism*
  • Tetrahydronaphthalenes / pharmacology

Substances

  • Antidepressive Agents
  • Benzopyrans
  • Ligands
  • Piperazines
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Tetrahydronaphthalenes
  • 2-aminotetralin