Synthesis antimicrobial and antifungal activity of some new 3 substituted derivatives of 4-(2,4-dichlorophenyl)-5-adamantyl-1H-1,2,4-triazole

S Papakonstantinou-Garoufalias; N Pouli; P Marakos; A Chytyroglou-Ladas

doi:10.1016/s0014-827x(02)01227-2

Synthesis antimicrobial and antifungal activity of some new 3 substituted derivatives of 4-(2,4-dichlorophenyl)-5-adamantyl-1H-1,2,4-triazole

Farmaco. 2002 Dec;57(12):973-7. doi: 10.1016/s0014-827x(02)01227-2.

Authors

S Papakonstantinou-Garoufalias¹, N Pouli, P Marakos, A Chytyroglou-Ladas

Affiliation

¹ Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, 157 71 Athens, Greece.

PMID: 12564470
DOI: 10.1016/s0014-827x(02)01227-2

Abstract

The synthesis of a series of substituted hydrazones and thiazolidinones is described, starting from N-[4-(2,4-dichlorophenyl)-5-adamantyl-1H-1,2,4-triazol-3-ylmercaptoacetyl]hydrazine. The new compounds were tested for antimicrobial and antifungal activity and some of them exhibited moderate activity against Candida albicans.

MeSH terms

Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis*
Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Candida albicans / drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects
Triazoles / chemical synthesis*
Triazoles / chemistry
Triazoles / pharmacology

Substances

4-(2,4-dichlorophenyl)-5-adamantyl-1H-1,2,4-triazole
Anti-Bacterial Agents
Anti-Infective Agents
Antifungal Agents
Triazoles