[Detection of Epstein-Barr virus and human papillomavirus in sinonasal malignant neoplasms]

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000 Aug;14(8):347-8.
[Article in Chinese]

Abstract

Objective: To investigate the existance of Epstein-Barr virus (EBV) and papilloma virus(HPV) in sinonasal malignant neoplasms.

Method: EBV and HPV (including HPV6,11,16,18,33) gene were detected in paraffin-embedded tissues with polymerase chain reaction(PCR) from 32 cases of sinonasal malignant neoplasms.

Result: EBV was detected in 12(37.5%), HPV in 21(65.6%); The coinfection of EBV and HPV was found in 6 cases with stage III-IV by TNM; 10 cases of nasal polyps contained neither EBV nor HPV.

Conclusion: Like HPV, there may be relationship between EBV and sinonasal malignant neoplasms. The coinfection of EBV and HPV is related to stage III-IV by TNM of sinonasal malignant neoplasms.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Epstein-Barr Virus Infections
  • Female
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Nose Neoplasms / pathology
  • Nose Neoplasms / virology*
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections
  • Paranasal Sinus Neoplasms / pathology
  • Paranasal Sinus Neoplasms / virology*
  • Tumor Virus Infections