Synthesis of alkyl and aryl esters of N-protected beta-homoamino acids from N-protected alpha-aminodiazoketones

G R Vasanthakumar; H N Gopi; V V Suresh Babu

doi:10.2174/0929866023408364

Synthesis of alkyl and aryl esters of N-protected beta-homoamino acids from N-protected alpha-aminodiazoketones

Protein Pept Lett. 2002 Dec;9(6):529-32. doi: 10.2174/0929866023408364.

Authors

G R Vasanthakumar¹, H N Gopi, V V Suresh Babu

Affiliation

¹ Department of Studies in Chemistry, Central College Campus, Dr B R Ambedkar Veedhi, Bangalore University, Bangalore 560 001, India.

PMID: 12553861
DOI: 10.2174/0929866023408364

Abstract

A simple and concomitant esterification method for the synthesis of methyl, ethyl, t-butyl, benzyl, and 9-fluorenylmethyl esters of Fmoc-/Boc-/Z-beta-homoamino acids employing Fmoc-/Boc-/Z-alpha-aminodiazoketones by Wolff rearrangement is described. The method offers good yield with purity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkylation
Amino Acids / chemical synthesis*
Amino Acids / chemistry
Esters / chemical synthesis*
Esters / chemistry
Ketones / chemistry*

Substances

Amino Acids
Esters
Ketones