Abstract
In cases of refractory status epilepticus (RSE) unresponsive to sequential trials of multiple agents, a suspension of topiramate administered via nasogastric tube was effective in aborting RSE, including one patient in a prolonged pentobarbital coma. Effective dosages ranged from 300 to 1,600 mg/d. Except for lethargy, no adverse events were reported.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adult
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Aged
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Anticonvulsants / administration & dosage
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Anticonvulsants / therapeutic use*
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Databases, Factual / statistics & numerical data
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Drug Resistance* / physiology
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Female
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Fructose / administration & dosage
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Fructose / analogs & derivatives*
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Fructose / therapeutic use*
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Humans
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Intubation, Gastrointestinal
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Male
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Middle Aged
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Retrospective Studies
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Status Epilepticus / drug therapy*
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Topiramate
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Treatment Outcome
Substances
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Anticonvulsants
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Topiramate
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Fructose