The use of topiramate in refractory status epilepticus

Neurology. 2003 Jan 28;60(2):332-4. doi: 10.1212/01.wnl.0000042783.86439.27.

Abstract

In cases of refractory status epilepticus (RSE) unresponsive to sequential trials of multiple agents, a suspension of topiramate administered via nasogastric tube was effective in aborting RSE, including one patient in a prolonged pentobarbital coma. Effective dosages ranged from 300 to 1,600 mg/d. Except for lethargy, no adverse events were reported.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adult
  • Aged
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / therapeutic use*
  • Databases, Factual / statistics & numerical data
  • Drug Resistance* / physiology
  • Female
  • Fructose / administration & dosage
  • Fructose / analogs & derivatives*
  • Fructose / therapeutic use*
  • Humans
  • Intubation, Gastrointestinal
  • Male
  • Middle Aged
  • Retrospective Studies
  • Status Epilepticus / drug therapy*
  • Topiramate
  • Treatment Outcome

Substances

  • Anticonvulsants
  • Topiramate
  • Fructose