Novel chromone derivatives from the fungus Aspergillus versicolor isolated from the marine sponge Xestospongia exigua

J Nat Prod. 2003 Jan;66(1):57-61. doi: 10.1021/np020196b.

Abstract

From the marine sponge Xestospongia exigua collected in Indonesia the fungus Aspergillus versicolor was isolated. Following cultivation in a seawater-based medium seven new angular tricyclic chromone derivatives (1-7) were obtained from the mycelia and culture filtrate. Compounds 2-7 contain an additional dihydropyran ring system which is replaced by a pyridine ring in 1. The structures of the new natural products were established on the basis of extensive one- and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, NOE difference spectra) as well as on mass spectral analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Aspergillus / chemistry*
  • Bacillus subtilis / drug effects
  • Chromones / chemistry
  • Chromones / isolation & purification*
  • Chromones / pharmacology
  • Cyclization
  • Escherichia coli / drug effects
  • Heterocyclic Compounds, 3-Ring / chemistry
  • Heterocyclic Compounds, 3-Ring / isolation & purification*
  • Heterocyclic Compounds, 3-Ring / pharmacology
  • Indonesia
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Saccharomyces cerevisiae / drug effects

Substances

  • Anti-Bacterial Agents
  • Chromones
  • Heterocyclic Compounds, 3-Ring
  • aspergillitine