NO-inhibiting and vasotropic activity of some compounds with thioamidine group

S Ya Proskuryakov; N G Kucherenko; A I Trishkina; M V Filimonova; A G Shevchuk; L V Shtein; Yu G Verkhovskii; A G Konoplyannikov; A A Mandrugin; V M Fedoseev; V G Skvortsov

doi:10.1023/a:1021943811672

NO-inhibiting and vasotropic activity of some compounds with thioamidine group

Bull Exp Biol Med. 2002 Oct;134(4):338-41. doi: 10.1023/a:1021943811672.

Authors

S Ya Proskuryakov¹, N G Kucherenko, A I Trishkina, M V Filimonova, A G Shevchuk, L V Shtein, Yu G Verkhovskii, A G Konoplyannikov, A A Mandrugin, V M Fedoseev, V G Skvortsov

Affiliation

¹ Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia.

PMID: 12533753
DOI: 10.1023/a:1021943811672

Abstract

Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressure and enhanced respiration rate. This effect probably reflects inhibition of not only inducible, but also the constitutive synthesis of NO by compounds with thioamidine group.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Endotoxins
Enzyme Inhibitors / pharmacology*
Liver / drug effects
Liver / enzymology
Male
Mice
Nitric Oxide / antagonists & inhibitors*
Nitric Oxide Synthase / antagonists & inhibitors
Rats
Rats, Wistar
Respiration / drug effects
Species Specificity
Thiazines / pharmacology*
Thiazoles / pharmacology*
Vasoconstrictor Agents / pharmacology*

Substances

Endotoxins
Enzyme Inhibitors
Thiazines
Thiazoles
Vasoconstrictor Agents
Nitric Oxide
Nitric Oxide Synthase