Abstract
Accumulating evidence has recognized phospholipase D (PLD) as an important element in signal transduction of cell responses, including proliferation and differentiation, However, its role in pro-apoptotic, anti-apoptotic or pro-survival signaling is not well-understood. Involvement of PLD in these signaling mechanisms is considered to differ depending on the cell type and the extracellular stimulus.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / physiology*
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Cell Hypoxia
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Cell Line
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Cell Membrane / enzymology
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Cell Survival
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Enzyme Activation
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Humans
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Monomeric GTP-Binding Proteins / metabolism
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Phosphatidylinositol 3-Kinases / metabolism
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Phospholipase D / antagonists & inhibitors
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Phospholipase D / genetics
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Phospholipase D / physiology*
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Protein Kinases / metabolism
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-akt
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RNA, Messenger / analysis
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Signal Transduction
Substances
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Proto-Oncogene Proteins
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RNA, Messenger
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Protein Kinases
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt
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Phospholipase D
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Monomeric GTP-Binding Proteins